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1.
Epidemiol. serv. saúde ; 30(1): e2020513, 2021. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1154140

ABSTRACT

Objetivo: Descrever as medidas de contenção de tipo lockdown e a incidência da COVID-19 em sete países: África do Sul, Alemanha, Brasil, Espanha, Estados Unidos, Itália e Nova Zelândia. Métodos: Estudo ecológico descritivo, com dados da incidência diária dos casos confirmados de COVID-19 entre 22 de fevereiro e 31 de agosto de 2020, e informações sobre medidas de lockdown implementadas pelo governo de cada país. Resultados: Os países que implementaram lockdown tiveram diminuição da incidência diária de COVID-19 (casos por milhão de habitantes) no período de três semanas, a contar do início da medida: África do Sul (3,7 a 1,7), Alemanha (37,5 a 33,7), Espanha (176,3 a 82,0), Itália (92,0 a 52,1) e Nova Zelândia (7,5 a 1,7). O Brasil e os Estados Unidos, que não implementaram lockdown, não apresentaram uma diminuição considerável. Conclusão: Após a implementação de lockdown, houve uma diminuição considerável do número de casos confirmados.


Objetivo: Describir las medidas de contención tipo lockdown y la incidencia de COVID-19 en los países de Sudáfrica, Alemania, Brasil, España, Estados Unidos, Italia y Nueva Zelanda. Métodos: Estudio ecológico descriptivo con datos de la incidencia diaria de los casos confirmados de COVID-19, del 22 de febrero al 31 de agosto de 2020 e informaciones sobre medidas de contención lockdown implementadas por los gobiernos de cada uno de los países. Resultados: Los países que implementaron lockdown, desde el inicio de su implementación hasta tres semanas después, tuvieron una disminución en la incidencia diaria (casos por millón de habitantes): Sudáfrica (3,7 a 1,7), Alemania (37,5 a 33,7), España (176,3 a 82,0), Italia (92,0 a 52,1) y Nueva Zelanda (7,5 a 1,7). Brasil y Estados Unidos, que no implementaron lockdown, no tuvieron una disminución considerable Conclusión: Luego de la implementación del lockdown, hubo una disminución considerable en el número de casos confirmados.


Objective: To describe lockdown-type containment measures and COVID-19 incidence in South Africa, Germany, Brazil, Spain, United States, Italy and New Zealand. Methods: This is a descriptive ecological study with data on daily incidence of confirmed COVID-19 cases from February 22 to August 31 2020, as well as information on lockdown measures implemented by the governments of each country. Results: Daily COVID-19 incidence (cases per 1 million inhabitants) decreased within three weeks after lockdown started in the countries that implemented it: South Africa (3.7 to 1.7), Germany (37.5 to 33.7) Spain (176.3 to 82.0), Italy (92.0 to 52.1) and New Zealand (7.5 to 1.7). As for Brazil and the United States, which did not implement lockdown, there was no considerable decrease. Conclusion: After lockdown implementation, there was a considerable decrease in the number of confirmed cases.


Subject(s)
Humans , Psychological Distance , Quarantine/methods , Communicable Disease Control/statistics & numerical data , Coronavirus Infections/prevention & control , Coronavirus Infections/epidemiology , South Africa/epidemiology , Spain/epidemiology , United States/epidemiology , Brazil/epidemiology , Incidence , Ecological Studies , Pandemics/prevention & control , Germany/epidemiology , Health Policy/trends , Italy/epidemiology , New Zealand/epidemiology
2.
Braz. j. otorhinolaryngol. (Impr.) ; 86(3): 294-299, May-June 2020. tab, graf
Article in English | LILACS | ID: biblio-1132593

ABSTRACT

Abstract Introduction: South Africa has a high prevalence of co-existing tuberculosis and HIV. As ototoxicity linked to the treatments for these conditions occurs with concomitant exposure to other ear toxins such as hazardous noise exposure, it is important to investigate the combination impact of these toxins. Limited published evidence exists on the co-occurrence of these conditions within this population. Objectives: The objective of this study was to compare the hearing function of gold miners with (treatment group) and without (non-treatment group) the history of tuberculosis treatment, in order to determine which group had increased risk of noise induced hearing loss. Furthermore, possible influence of age and HIV in these two groups was examined. Methods: A retrospective record review of 102 miners' audiological records, divided into two groups, was conducted, with data analyzed both qualitatively and quantitatively. Results: Findings suggest that gold miners with a history of tuberculosis treatment have worse hearing thresholds in the high frequencies when compared to those without this history; with evidence of a noise induced hearing loss notch at 6000 Hz in both groups. Pearson's correlations showed values between 0 and 0.3 (0 and −0.3) which are indicative of a weak positive (negative) correlation between HIV and hearing loss, as well as between hearing loss and age in this population. Conclusions: Current findings highlight the importance of strategic hearing conservation programs, including ototoxicity monitoring, and the possible use of oto-protective/chemo-protective agents in this population.


Resumo Introdução: A África do Sul apresenta uma alta prevalência de coinfecção de tuberculose e HIV. Como a ototoxicidade associada aos tratamentos para essas condições é observada na exposição concomitante a outros agentes ototóxicos, como a exposição a ruídos perigosos, é importante investigar o impacto da combinação desses agentes. São poucas as evidências publicadas sobre a co-ocorrência dessas condições nessa população. Objetivo: Comparar a função auditiva de garimpeiros com (grupo tratamento) e sem (grupo sem tratamento) história de tratamento de tuberculose, a fim de determinar que grupo apresentava maior risco de perda auditiva induzida por ruído. Além disso, avaliou-se a possível influência da idade e do HIV nesses dois grupos. Método: Os registros audiológicos de 102 garimpeiros, divididos em dois grupos, foram revisados de forma retrospectiva; os dados foram qualitativa e quantitativamente analisados. Resultados: Os achados indicam os garimpeiros com histórico de tratamento de tuberculose apresentam piores limiares auditivos nas altas frequências quando comparados àqueles sem esse histórico; em ambos os grupos, observou-se perda auditiva induzida por ruído com entalhe audiométrico a 6.000 Hz. As correlações de Pearson mostraram valores entre 0 e 0,3 (0 e -0,3), que são indicativos de uma fraca correlação positiva (negativa) entre o HIV e a perda auditiva, bem como entre a perda auditiva e a idade nessa população. Conclusões: Os resultados atuais destacam a importância de programas estratégicos de conservação auditiva, inclusive monitoramento de ototoxicidade, e o possível uso de agentes oto-/quimioprotetores nessa população.


Subject(s)
Humans , Adolescent , Adult , Middle Aged , Young Adult , Tuberculosis/epidemiology , Occupational Exposure/adverse effects , Gold , Hearing Loss, Noise-Induced/epidemiology , Mining , Noise, Occupational/adverse effects , Occupational Diseases/epidemiology , South Africa/epidemiology , Prevalence , Cross-Sectional Studies , Retrospective Studies , Risk Factors , Hearing Loss, Noise-Induced/diagnosis , Hearing Tests
3.
Braz. j. infect. dis ; 23(6): 371-380, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1089307

ABSTRACT

ABSTRACT Introduction: The presence of Acinetobacter baumannii outside hospitals remains unclear. This study aimed to determine the prevalence of multidrug-resistance (MDR) A. baumannii in the extra-hospital environment in Mthatha, South Africa and to investigate the frequency of carbapenemase-encoding genes. Material and Methods: From August 2016 to July 2017 a total of 598 abattoir samples and 689 aquatic samples were collected and analyzed presumptively by cultural methods for the presence of A. baumannii using CHROMagar™ Acinetobacter medium. Species identification was performed by autoSCAN-4 (Dade Behring Inc., IL) and confirmed by the detection of their intrinsic blaOXA-51 gene. Confirmed MDR A. baumannii isolates were screened for the presence of carbapenemase-encoding genes, ISAba1 insertion sequence and integrase intI1. Results: In total, 248 (19.3%) Acinetobacter species were isolated. Acinetobacter. baumannii was detected in 183 (73.8%) of which 85 (46.4%) and 98 (53.6%) were recovered from abattoir and aquatic respectively. MDR A. baumannii was detected in 56.5% (48/85) abattoir isolates and 53.1% (52/98) aquatic isolates. Isolates showed high resistance to antimicrobials most frequently used to treat Acinetobacter infections such as piperacillin/tazobactam; abattoir (98% of isolates resistant), aquatic (94% of isolates resistant), ceftazidime (84%, 83%), ciprofloxacin (71%, 70%), amikacin (41%, 42%), imipenem (75%, 73%), and meropenem (74%, 71%). All the isolates were susceptible to tigecycline and colistin. All the isolates carried blaOXA-51-like. The blaOXA-23 was detected in 32 (66.7%) abattoir isolates and 11 (21.2%) aquatic isolates. The blaOXA-58-like was positive in 7 (14.6%) and 4 (7.7%) abattoir and aquatic isolates, respectively. Both groups of isolates lacked blaOXA-24-like, blaIMP-type, blaVIM-type, blaNDM-1, blaSIM, blaAmpC, ISAba1 and inI1. Isolates showed high level of Multiple Antibiotic Resistance Index (MARI) ranging from 0.20-0.52. Conclusion: Extra-hospital sources such as abattoir and aquatic environments may be a vehicle of spread of MDR A. baumannii strains in the community and hospital settings.


Subject(s)
Humans , Acinetobacter Infections/microbiology , Acinetobacter Infections/drug therapy , Drug Resistance, Multiple, Bacterial/genetics , Acinetobacter baumannii/isolation & purification , Anti-Bacterial Agents/therapeutic use , South Africa/epidemiology , Acinetobacter Infections/transmission , Acinetobacter Infections/epidemiology , Microbial Sensitivity Tests , Polymerase Chain Reaction , Prevalence , Cross-Sectional Studies , Prospective Studies , Acinetobacter baumannii/genetics
4.
J. venom. anim. toxins incl. trop. dis ; 24: 20, 2018. tab, graf, ilus
Article in English | LILACS | ID: biblio-954856

ABSTRACT

Yellow fever was transported during the slave trade in the 15th and 16th centuries from Africa to the Americas where the virus encountered favorable ecological conditions that allowed creation of a sustainable sylvatic cycle. Despite effective vector control and immunization programs for nearly a century, yellow fever epidemics reemerged in many Latin American countries, particularly Brazil. The emergence or reemergence of vector-borne diseases encompasses many intricate factors. Yellow fever outbreaks occur if at least three conditions are fulfilled: the introduction of the virus into a non-immune human community, presence of competent and anthropophilic vectors and insufficiency of prevention and/or adequate management of the growing outbreak. On the other hand, two weapons are available to constrain yellow fever: vector control and immunization. In contrast, yellow fever is absent from Asia and the Pacific despite the presence of the vector and the susceptibility of human populations to the virus. Based on a review of the global history of yellow fever and its epidemiology, the authors deliver some recommendations for improving the prevention of epidemics.(AU)


Subject(s)
Humans , Male , Female , Yellow Fever/history , Asia/epidemiology , South Africa/epidemiology , Americas/epidemiology , Brazil/epidemiology
5.
The Korean Journal of Internal Medicine ; : 219-236, 2016.
Article in English | WPRIM | ID: wpr-36009

ABSTRACT

Rheumatoid arthritis (RA) is expected to increase in Africa and South Africa. Due to the low numbers of rheumatologists in South Africa, specialist physicians also have to care for patients with RA. Furthermore several new developments have taken place in recent years which improved the management and outcome of RA. Classification criteria were updated, assessment follow-up tools were refined and above all, several new biological disease-modifying anti-rheumatic drugs were developed. Therefore it is imperative for specialist physicians to update themselves with the newest developments in the management of RA. This article provides an overview of the newest developments in the management of RA in the South African context. This approach may well apply to countries with similar specialist to patient ratios and disease profiles.


Subject(s)
Humans , Antirheumatic Agents/adverse effects , Arthritis, Rheumatoid/diagnosis , Diffusion of Innovation , Practice Guidelines as Topic , Practice Patterns, Physicians' , Prevalence , Rheumatologists/standards , Risk Factors , Severity of Illness Index , South Africa/epidemiology , Specialization , Treatment Outcome
6.
Ciênc. Saúde Colet. (Impr.) ; 20(9): 2641-2648, Set. 2015.
Article in Portuguese | LILACS | ID: lil-757523

ABSTRACT

ResumoO presente texto apresenta aspectos pertinentes à restituição dos dados da pesquisa antropológica aplicada à saúde, a partir do relato de experiências de pesquisas etnográficas realizadas no Brasil e na França. Tais experiências mostram que a restituição dos dados fez parte do escopo da pesquisa, com modalidades e temporalidades diversas, permitindo prolongar o tempo de trabalho de campo e as interações com os indivíduos pesquisados. Da mesma forma, possibilitou trocas entre os interlocutores e confrontos de diferentes pontos de vista, trazendo novos dados e, assim, enriquecendo as pesquisas. Esses aspectos suscitaram questões importantes para reflexão, do ponto de vista ético e epistemológico. Uma delas diz respeito às demandas feitas aos antropólogos da saúde no momento de inserção do campo e como as mesmas serão por eles tratadas: como o pesquisador restituirá os dados, sem receio de vê-los ser mal interpretados ou instrumentalizados de forma a reforçar padrões normativos? Nesse sentido, como “traduzir” o discurso antropológico? O pesquisador consciente busca validar suas análises, busca novos pontos de vista e interrogações. Assim, a restituição provoca novas inquietações e interpretações na forma de reflexividade.


AbstractThis study examines relevant aspects about the way anthropological research data restitution has been applied in the area of health, based on data obtained from ethnographic field research conducted in Brazil and France. These experiences show that data restitution has been part of the area of research, in different forms and time frames, making it possible to extend periods spent in the field and to interact with individual respondents. This also made it possible to interact with research interlocutors and compare different points of view, adding new information and thereby enriching the research. These aspects raise important questions that require reflection, from an ethical and epistemological standpoint. One is related to the demands made on health anthropologists when they begin their field research and how they deal with these questions: how will researchers use the data they collect without worrying that this may be wrongly interpreted or used in some way to reinforce normative patterns? So, how should an anthropological debate be “translated”? Conscientious researchers will seek to validate their analysis, to discover new points of view and provoke new lines of questioning. Thus, such data should provoke reflexivity about new avenues of research and interpretations.


Subject(s)
Adult , Female , Humans , Male , Condoms/statistics & numerical data , Depression/epidemiology , HIV Infections/epidemiology , Research Design , Social Stigma , Social Support , Unsafe Sex/statistics & numerical data , Condoms , Depression/prevention & control , HIV Infections/prevention & control , HIV Infections/psychology , Health Knowledge, Attitudes, Practice , Health Surveys , Longitudinal Studies , Poverty , Prevalence , Risk Factors , Sexual Partners , South Africa/epidemiology , Surveys and Questionnaires
7.
West Indian med. j ; 62(7): 582-588, Sept. 2013. graf, tab
Article in English | LILACS | ID: biblio-1045708

ABSTRACT

OBJECTIVE: To explore gender and racial profiling of percentage body fat of 1136 urban South African children attending public schools in Pretoria Central. METHODS: This is a cross-sectional survey of 1136 randomly selected children (548 boys and 588 girls) aged 9-13 years in urban (Pretoria Central) South Africa. Body mass, stature, skinfolds (subscapular and triceps) were measured. Data were analysed using descriptive statistics (means and standard deviations). Differences in the mean body fat percentage were examined for boys and girls according to their age group/race, using independent t-test samples. RESULTS: Girls had a significantly (p = 0.001) higher percentage body fat (22.7 ±5.7% (95% CI = 22.3, compared to boys (16.1 ± 7.7%, 95% CI = 15.5, 16.8). Percentage body fat fluctuated with age in both boys and girls. Additionally, girls had significantly (p = 0.001) higher percentage body fat measurements at all ages compared to boys. Viewed racially, black children (20.1 ± 7.5) were significantly (p = 0.010) fatter than white children (19.0 ± 7.4) with a mean difference of 4.0. Black children were fatter than white children at ages 9, 10, 12 and 13 years, with a significant difference (p = 0.009) observed at age 12 years. CONCLUSION: There was a considerably higher level of excessive percentage body fat among school children in Central Pretoria, South Africa, with girls having significantly higher percentage body fat compared to boys. Racially, black children were fatter than white children. The excessive percentage body fat observed among the children in this study has implications for their health and fitness. Therefore, an intervention programme must be instituted in schools to prevent and control possible excessive percentage body fat in this age group.


OBJETIVO: Explorar la evaluación por perfil de raza y género del porcentaje de grasa corporal de 1136 niños sudafricanos de áreas urbanas, que asisten a escuelas públicas en Pretoria Central. MÉTODOS: Se trata de un estudio transversal de 1136 niños seleccionados aleatoriamente (548 niños y 588 niñas) de 9-13 años de edad en Sudáfrica urbana (Pretoria Central). Se midieron la masa corporal, la estatura, y los pliegues cutáneos (tríceps y subescapular). Los datos fueron analizados mediante estadística descriptiva (medias y desviaciones estándar). Se examinaron las diferencias en el porcentaje degrasa corporal promedio de niñosyniñas según su grupo de edad/raza, utilizando prueba t para muestras independientes. RESULTADOS: Las niñas presentaban un porcentaje de grasa corporal (22.7 ±5.7%, 95% CI= 22.3, 23.2) significativamente mayor (p = 0.001) en comparación con los niños (16.1 ± 7.7%, 95% CI = 15.5, 16.8). El porcentaje de grasa corporal fluctuó con la edad tanto en los niños como en las niñas. Además, las niñas presentaron mediciones de grasa corporal significativamente más altas (p = 0.001) para todas las edades, en comparación con los niños. Racialmente, los niños negros (20.1 ± 7.5) fueron significativamente (p = 0.010) más gordos que los niños blancos (19.0 ± 7.4) con una diferencia media de 4.0. Los niños negros eran más gordos que los niños blancos en las edades de 9, 10, 12 y 13 años, con una diferencia significativa (p = 0.009) observada en la edad de 12 años. CONCLUSIÓN: Hubo un nivel considerablemente superior de porcentaje de grasa corporal excesiva entre los escolares de Pretoria Central, Sudáfrica, poseyendo las niñas un porcentaje de grasa corporal significativamente mayor que los niños. Racialmente, los niños negros eran más gordos que los niños blancos. El porcentaje de grasa corporal excesiva observada entre los niños de este estudio tiene implicaciones para su salud y su condición física. Por lo tanto, un programa de intervención debe ser instituido en las escuelas para prevenir y controlar posibles excesos en ea porcentaje de grasa corporal en este grupo etario.


Subject(s)
Humans , Male , Female , Child , Adolescent , Urban Population/statistics & numerical data , Body Composition , Health Status , Physical Fitness , South Africa/epidemiology , Adipose Tissue , Cross-Sectional Studies , Black People/statistics & numerical data , White People/statistics & numerical data
8.
West Indian med. j ; 58(3): 277-282, June 2009.
Article in English | LILACS | ID: lil-672485

ABSTRACT

Poverty, cultural belief and refusal to use condoms are some of the factors that contribute to the spread of HIV infection among African communities. There is a dire need to pursue research into the development, provision and the use of microbicides for African women. This review paper provides information and recommendations on the possible use of microbicides to prevent HIV infection among African women.


La pobreza, las creencias culturales, y el rechazo al uso del condón son algunos de los factores que contribuyen a diseminar la infección por VIH entre las comunidades africanas. Se necesita emprender con urgencia investigaciones encaminadas a desarrollar, suministrar, y usar microbicidas entre las mujeres africanas. El presente estudio ofrece información y recomendaciones sobre el posible uso de microbicidas a fin de prevenir la infección por VIH entre las mujeres africanas.


Subject(s)
Animals , Female , Humans , Anti-Infective Agents/therapeutic use , HIV Infections/prevention & control , Anti-HIV Agents/therapeutic use , HIV Infections/epidemiology , HIV Infections/transmission , Preventive Medicine , Sexually Transmitted Diseases/prevention & control , South Africa/epidemiology
9.
Physis (Rio J.) ; 19(2): 283-300, 2009.
Article in Portuguese | LILACS, BDS | ID: lil-530612

ABSTRACT

Este artigo é uma tentativa de refletir sobre as respostas governamentais à epidemia de Aids a partir de dois casos contraditórios: Brasil e África do Sul. A partir do exame das trajetórias da epidemia em ambos os países e da ampla literatura escrita sobre o tema, busca-se entender o porquê de ações governamentais tão díspares em países que são, do ponto de vista socioeconômico, relativamente semelhantes. A hipótese aqui sustentada é que as inter-relações entre instituições políticas e processos mais amplos de construção da identidade nacional podem explicar as distintas respostas governamentais e iluminar a complexa relação entre Aids, sexualidade, raça e identidade nacional no Brasil e na África do Sul.


This paper attempts to analyze the governmental responses to Aids epidemic in two conflicting cases: Brazil and South Africa. Drawing on the examination of Aids epidemic's trajectories in both countries and the extensive literature about that thematic, we try to comprehend the reason for such diversified governmental responses to those similar sociopolitical contexts. The paper supports that the inter-relations between political institution and wider processes of nation-building can explain such different governmental responses to Aids and illuminate the complex relationship between Aids, sexuality, race and national identity in Brazil and South Africa.


Subject(s)
South Africa/epidemiology , Brazil/epidemiology , Sexually Transmitted Diseases/prevention & control , Politics , Health Policy , Socioeconomic Factors , Acquired Immunodeficiency Syndrome/epidemiology , Cultural Characteristics , Health Management , Prejudice , Sexuality
10.
J Health Popul Nutr ; 2008 Dec; 26(4): 405-17
Article in English | IMSEAR | ID: sea-970

ABSTRACT

The purpose of this observational prospective cohort study was to investigate the development and tracking of body mass index (BMI) of Ellisras rural children from preschool age into late adolescence from the Ellisras Longitudinal Growth and Health Study. Heights and weights of children were measured according to the standard procedures recommended by the International Society for the Advancement of Kinanthropometry twice a year from 1996 to 2003. In total, 2,225 children--550 preschool and 1,675 primary school--aged 3-10 years (birth cohorts 1993 to 1986) were enrolled at baseline in 1996 and followed through out the eight-year periodic surveys. In 2003, 1,771 children--489 preschool and 1,282 primary school--were still in the study. The prevalence of overweight was significantly higher among girls (range 1.6-15.5%) compared to boys (range 0.3-4.9%) from age 9.1 years to 14.9 years. The prevalence of thinness (severe, moderate, and mild) ranged from 7.1% to 53.7% for preschool children and from 8.0% to 47.6% for primary school children. Both preschool and primary school children showed a significant association between the first measurements of BMI and the subsequent measurement which ranged from B=0.2 (95% confidence interval [CI] 0.1-0.4) to B=0.8 (95% CI 0.6-0.9) for preschool and B=0.2 (95% CI 0.1-0.3) to B=0.7 (95% CI 0.6-0.8) for primary children. A significant tracking of BMI during 4-12 years of life was more consistent for preschool children (B=0.6 (95% CI 0.6-0.7) and for primary school children (B=0.6 (95% CI 0.5-0.6). Investigation of nutritional intake and physical activity patterns will shed light on how healthy these children are and their lifestyle.


Subject(s)
Adolescent , Age Distribution , Anthropometry , Body Height/physiology , Body Mass Index , Body Weight/physiology , Child , Child, Preschool , Cohort Studies , Female , Health Surveys , Humans , Longitudinal Studies , Male , Obesity/epidemiology , Overweight/epidemiology , Prevalence , Prospective Studies , Rural Population/statistics & numerical data , Severity of Illness Index , Sex Distribution , South Africa/epidemiology , Thinness/epidemiology
11.
J Health Popul Nutr ; 2007 Dec; 25(4): 406-13
Article in English | IMSEAR | ID: sea-985

ABSTRACT

Campylobacter species are increasingly being recognized as agents of gastroenteritis worldwide. However, data on the pathogenic characteristics of the organism isolated in rural communities in South Africa are lacking. In this study, the prevalence of Campylobacter spp. from diarrhoeal stools, haemolytic and haemagglutinating activities of the isolates, and antibiotic susceptibility profiles, including minimum inhibitory concentration (MIC) patterns to different antibiotics, were determined using the standard microbiological techniques. Campylobacter spp. were isolated from individuals of all age-groups; however, the infection rate was higher among individuals aged less than two years (30.4%). Of 115 Campylobacter strains isolated, polymerase chain reaction (PCR) analysis indicated that 98 (85%) were C. jejuni, while 17 (15%) were C. coli. Seventy-one (62%) of the strains showed haemolysis on human blood, and 80% agglutinated human blood, whereas 22.6% were beta-lactamase-positive. Resistance to antimicrobials, such as erythromycin, ciprofloxacin, vancomycin, and fusidic acid, was high. Increased resistance to macrolide and quinolone antibiotics poses major risks for treatment failure. Haemolytic and haemagglutinating activities may be useful in preliminary characterization of pathogenic strains in settings where Campylobacter-associated infections are common.


Subject(s)
Adolescent , Adult , Aged , Anti-Bacterial Agents/therapeutic use , Campylobacter/drug effects , Campylobacter Infections/drug therapy , Child , Child, Preschool , Colony Count, Microbial , Diarrhea/drug therapy , Drug Resistance, Bacterial , Female , Hemagglutination , Humans , Infant , Infant, Newborn , Male , Microbial Sensitivity Tests , Middle Aged , Prevalence , South Africa/epidemiology , Treatment Outcome
12.
J Health Popul Nutr ; 2007 Dec; 25(4): 428-35
Article in English | IMSEAR | ID: sea-573

ABSTRACT

The prevalence, pathogenic indices, such as haemolytic and haemagglutinating activities, antibiograms, and in-vitro activities of local medicinal plants against Aeromonas isolates in Vhembe district of Limpopo province, South Africa, were studied using standard microbiological methods. In total, 309 diarrhoeic stool samples were collected from patients attending five health centres in the region during December 2004-May 2005. Aeromonas species were identified using the API 20E system. The haemagglutinating and haemolytic activities of isolates on human, sheep, pig and chicken red blood cells were investigated. Antibiotic susceptibility profiles of the isolates to several antibiotics and in-vitro activity of local medicinal plants were also ascertained using previously-reported schemes. Results showed that 104 (33.6%) of the 309 samples were positive for Aeromonas species, of which 89 (85.6%) were Aeromonas hydrophila, 12 (11.5%) A. sobria, and three (2.9%) A. caviae. All strains of A. hydrophila and A. caviae produced haemolysis on sheep blood, while eight of the 12 A. sobria strains were haemolytic on sheep blood. The haemolytic activities of the isolates were variable on other red blood cells tested. High level of resistance was observed to amoxicillin and ampicillin, followed by cefuroxime (79%), chloramphenicol (74%), and erythromycin (65%). The carbapenems were the most active drugs with only 7% resistance to meropenem and 11% to imipenem. About 12% of the isolates were resistant to ciprofloxacin. The extracts of three of seven medicinal plants tested showed inhibitory activity against all Aeromonas isolates; these included acetone and hexane extracts of Pterocarpus angolensis, Syzygium cordatum, and Zornia milneana. The results suggest a high prevalence of Aeromonas species in the region. The isolates demonstrated multiple resistant profiles to different antibiotics tested. Some local medicinal plants were inhibitory to Aeromonas isolates, indicating a potential role in the management of Aeromonas-related infections. Structural elucidation of the active components may pave the way for the discovery of candidate templates for eventual drug design. Most isolates possessed important virulence characteristics based on their haemolytic and haemagglutinating ability. However, the genetic characterization of the isolates will further confirm their pathogenicity and the origin of multiple antibiotic resistance.


Subject(s)
Adolescent , Adult , Aeromonas/drug effects , Anti-Bacterial Agents/pharmacology , Child , Child, Preschool , Drug Resistance, Bacterial , Drug Resistance, Multiple, Bacterial , Feces/microbiology , Female , Gram-Negative Bacterial Infections/drug therapy , Hemolysis , Humans , Infant , Infant, Newborn , Male , Microbial Sensitivity Tests , Middle Aged , Plant Extracts/pharmacology , Prevalence , South Africa/epidemiology
14.
J Health Popul Nutr ; 2005 Jun; 23(2): 150-5
Article in English | IMSEAR | ID: sea-975

ABSTRACT

Bacterial contaminants of Vhuswa--a traditional maize-based weaning food, and domestic drinking-water stored in impoverished rural households in Venda of Limpopo province, South Africa, were determined. One hundred and twenty-five samples of Vhuswa fed to children aged less than five years were assessed for Escherichia coli, Campylobacter jejuni, Salmonella, and Shigella. The microbiological quality of 125 drinking-water samples was also evaluated using total coliforms, faecal coliforms, and faecal streptococci as indicators. The frequency of isolation of E. coli, Salmonella, Shigella, and C. jejuni from the Vhuswa samples was 70%, 5%, 5%, and 2% respectively. The geometric mean counts of total coliforms, faecal coliforms, and faecal streptococci in tap-water stored in household containers ranged from 4.9x10(2) to 5.8x10(3) cfu 100 mL(-1), 2.6x10(2) to 3.7x10(3) cfu 100 mL(-1), and 3.1x10(3) to 5.8x10(3) cfu 100 mL(-1) respectively, and for stored spring water it was 5.1x10(3) cfu 100 mL(-1), 3.2x10(3) cfu 100 mL(-1), and 5.1x10(3) cfu 100 mL(-1) respectively. The frequent contamination of water and food samples in this study has important implications for the health of children from impoverished communities.


Subject(s)
Bacteria/isolation & purification , Child, Preschool , Colony Count, Microbial , Female , Food Contamination/analysis , Food Microbiology , Humans , Infant , Infant Food/microbiology , Infant, Newborn , Male , Rural Health , South Africa/epidemiology , Water Microbiology
15.
J Health Popul Nutr ; 2005 Mar; 23(1): 74-81
Article in English | IMSEAR | ID: sea-864

ABSTRACT

Despite the availability of effective treatment regimens, exceptionally high rates of tuberculosis persist in South Africa. A better understanding of public perceptions of tuberculosis is important for the improvement of the existing tuberculosis-control programmes. This study was aimed at investigating public perceptions about causes, suggested means of risk reduction, and preferred treatment of tuberculosis. The cross-sectional study included a sample of 80 community members from four different age groups chosen by quota sampling in a semi-urban community. Results indicated that 13.75% of the community members reported biomedical causes of tuberculosis, 35% suggested biomedical methods as a means for risk reduction, and 91.25% preferred medical treatment. Significant gender but not age difference was found. Women reported more often than men a biomedical cause of tuberculosis. A number of misconceptions about the cause and risk reduction of tuberculosis were also mentioned. The results suggest that people in a semi-urban area of the Limpopo province have limited knowledge and understanding of tuberculosis. It is suggested that healthcare workers provide services for increasing basic knowledge about causes and risk reduction of tuberculosis of the population in every age group.


Subject(s)
Adolescent , Adult , Child , Cross-Sectional Studies , Female , Health Knowledge, Attitudes, Practice , Humans , Male , Middle Aged , Perception , Risk Factors , Sex Factors , South Africa/epidemiology , Tuberculosis/drug therapy
16.
J Health Popul Nutr ; 2003 Sep; 21(3): 264-72
Article in English | IMSEAR | ID: sea-858

ABSTRACT

Decades of apartheid policies have resulted in marked racial inequalities in health in South Africa. The black:white rate ratio of diarrhoea among children aged less than five years, one of the five most common causes of infant and child deaths, stood at 6.5 in 1998. Using data from the 1998 South African Demographic and Health Survey, this paper examines the mechanisms of this racial disparity. The research confirms the presence of persistent racial inequalities in access to safe drinking-water and sanitation and in maternal education and household wealth, with the black population constituting the most disadvantaged group. While the living environment and access to safe drinking-water explain the excessive risk of diarrhoea among the black population compared to the coloured and Indian populations, the excessive risk of diarrhoea among the black population compared to the white population cannot be explained by disparities in the living environment, hygiene levels, and socioeconomic factors.


Subject(s)
Black People/statistics & numerical data , Child, Preschool , Diarrhea/economics , White People/statistics & numerical data , Family Characteristics , Female , Health Surveys , Humans , Infant , Infant, Newborn , Male , Poverty , Prejudice , Prevalence , Risk Factors , Sanitation/standards , Socioeconomic Factors , South Africa/epidemiology , Water Supply/standards
17.
J Health Popul Nutr ; 2003 Sep; 21(3): 205-15
Article in English | IMSEAR | ID: sea-756

ABSTRACT

The study was carried out to assess the magnitude of, and change in, inequities in self-reported adult illness and use of healthcare and to consider the policy implications of the findings. Datasets from three household surveys carried out in 1993, 1995, and 1998 were used. Inequities were measured using illness and healthcare-use concentration indices. Self-reported adult illness was greater among the rich in 1993, but this was reversed to reflect higher levels of reported illness among the poor in 1995 and 1998. Inequities were observed in self-reported injury and disability/chronic illness that favour the rich. The poor also reported more days of sickness compared to the rich. Overall, there were higher levels of use of doctors and hospital services by the rich, relative to their levels of reported illness. In contrast, there was a greater use of public-sector facilities by the poor. The time taken to reach a health facility also had a bias in favour of the rich. Although there were some favourable changes in the levels of inequities between the three time periods, there still remained considerable inequities that favoured the rich in self-reported adult illness and use of health services that need to be addressed. The consequences of higher concentration of chronic illness/disability and injury among the poor have far-reaching negative consequences on the socioeconomic welfare of the individuals and households. Redressing these inequities needs a holistic strategy that transcends the health sector.


Subject(s)
Adult , Health Services/statistics & numerical data , Health Services Accessibility/economics , Health Status Indicators , Health Surveys , Humans , Morbidity , Patient Acceptance of Health Care/statistics & numerical data , Self Disclosure , Social Class , Social Justice , Socioeconomic Factors , South Africa/epidemiology
19.
J Health Popul Nutr ; 2002 Dec; 20(4): 285-8
Article in English | IMSEAR | ID: sea-668

ABSTRACT

This paper explores the relationship among poverty, risky sexual behaviour, and vulnerability to HIV infection, using data from the 1998 South African Demographic and Health Survey. Asset index was employed as proxy of socioeconomic status. Inequalities in health were measured using concentration index. Women in poorer households were slightly less knowledgeable about HIV/AIDS, while the socioeconomic inequalities in risky sexual behaviour were negligible. These small health gradients may reflect the limitations of population-based surveys in collection of information on sexual behaviour. The results may also mean that women in general are equally at risk of HIV infection, which means that more work is required to establish how factors other than knowledge on HIV/ AIDS and socioeconomic status stand to enhance the vulnerability of women to HIV/AIDS.


Subject(s)
Adolescent , Adult , Female , HIV Infections/economics , Health Knowledge, Attitudes, Practice , Health Surveys , Humans , Middle Aged , Poverty/ethnology , Risk Factors , Sexual Behavior/ethnology , Social Class , South Africa/epidemiology , Women's Health
20.
Cad. saúde pública ; 18(3): 651-660, maio-jun. 2002.
Article in English | LILACS | ID: lil-330942

ABSTRACT

This paper presents an overview of the development of HIV/AIDS in South Africa, taking into consideration the social context and analyzing the factors most likely to have influenced its spread as well as the societal response to it. The authors argue that macro factors such as social and political structures, in addition to behavioral ones, have combined to shape the course of the epidemic. Since various factors linked to social inequalities have combined to shape the pattern and growth of the HIV/AIDS epidemic in South Africa, it is inappropriate to focus on only one dimension in an attempt to combat the epidemic. Following the psycho-socio- environmental model, all potential contributing elements need to be addressed simultaneously. This calls for a true interdisciplinary and multi-sectorial approach. It also requires great commitment as well as strong political will.


Subject(s)
Female , Humans , Male , Disease Outbreaks , Acquired Immunodeficiency Syndrome/epidemiology , South Africa/epidemiology , Demography , Risk Factors , Socioeconomic Factors
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